Fluoxetine (Prozac) is considered a strong inhibitor of which CYP enzyme?

Fluoxetine, commonly known by its brand name Prozac, is classified as a strong inhibitor specifically of the CYP2D6 enzyme. This enzyme plays a crucial role in the metabolism of various drugs, and fluoxetine's inhibition of CYP2D6 can significantly affect the clearance of medications that are substrates of this enzyme, leading to increased blood levels of those drugs and potentially resulting in enhanced therapeutic effects or adverse reactions.

Understanding the significance of fluoxetine's effect on CYP2D6 is important in clinical settings, especially when prescribing medications that are metabolized by this enzyme. This knowledge aids healthcare providers in making informed decisions regarding drug interactions, dosing adjustments, and monitoring of therapeutic responses in patients taking multiple medications.