Ethacrynic acid is known for having what risk compared to other loop diuretics?

Ethacrynic acid is particularly noted for having a higher risk of ototoxicity compared to other loop diuretics. Ototoxicity refers to damage to the inner ear, which can result in hearing loss or balance issues. This side effect is significant because, while all loop diuretics can potentially cause ototoxic effects, ethacrynic acid has been associated more consistently with these complications. This increased risk is especially relevant in patients who are receiving high doses or in the presence of renal impairment.

The other options do not indicate the distinct risks associated with ethacrynic acid. For instance, while dehydration is a common concern with any diuretic, it is not uniquely heightened with ethacrynic acid relative to its peers. Similarly, hypertension is not a known risk of loop diuretics; instead, these medications are typically used to manage conditions where fluid retention is a factor. Lastly, chronic kidney disease can occur in patients taking any diuretic, but it is not specifically linked with a higher incidence in those taking ethacrynic acid compared to other loop diuretics. Thus, the association of ethacrynic acid with a higher risk of ototoxicity is what makes the answer accurate.