Carmustine and Lomustine are primarily used in the treatment of which type of cancer?

Carmustine and Lomustine are both alkylating agents that belong to the nitrosoureas class of chemotherapy drugs. They are particularly effective in treating brain cancers, including gliomas and other types of central nervous system tumors. The reason these agents are commonly used for brain cancers is due to their ability to cross the blood-brain barrier, which is a significant challenge for many other chemotherapy agents. This unique property allows them to exert their therapeutic effects directly on tumors located in the brain.

Colorectal cancer, pancreatic cancer, and multiple myeloma are typically treated with different classes of chemotherapy and targeted therapies, which are more suitable for those specific cancers. Therefore, the focused use of Carmustine and Lomustine in the realm of brain tumors highlights their specialized role within oncology, making the identification of their primary application clear.