According to the provided information, what side effect is specifically associated with Trazodone?

Trazodone, primarily used as an antidepressant and sleep aid, has a notable side effect specifically associated with its use: priapism. Priapism is a rare but potentially serious condition characterized by a prolonged and often painful erection that lasts for hours without sexual stimulation. This side effect is significant because, if untreated, it can lead to permanent damage to the penile tissue.

The mechanism behind this side effect relates to Trazodone's action on serotonin receptors and its impact on vascular function. Since priapism can require emergency medical attention, it is crucial for healthcare providers to inform patients about this risk when prescribing Trazodone.

Other options like significant weight loss, hallucinations, and dry skin are not typically associated with Trazodone and are more common with other medications or conditions. Therefore, priapism stands out as a specific and noteworthy side effect linked directly to the use of Trazodone.